Round 13: Tossup 3

This genus’s namesake surface anion channel increases host membrane permeability for isoleucine. Histidine-rich proteins produced by this genus are either knob or membrane associated, the latter of which stabilize Maurer’s clefts. Individuals with deletions in the glycophorin C gene are less susceptible to infections by this genus but often suffer from elliptocytosis instead. Members of this genus are targeted by a sesquiterpene (“sesqui-terpene”) lactone isolated from Artemisia (10[1])herbs. Duffy binding proteins produced by this genus’s vivax and knowlesi (“NOLL-zee”) species target reticulocytes. Mutations in ABC transporter genes can confer quinine resistance to this genus’s falciparum species. For 10 points, name this protozoan genus harbored in the salivary glands of Anopheles mosquitoes, the causative agent of malaria. ■END■

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