Packet I: Bonus 3
Pax5 transcription factors play a major role in the differentiation of these cells by promoting the expression of their co-receptor CD19. For 10 points each:
[10e] Name these cells deficient in X-linked agammaglobulinemia, resulting in patients producing little antibodies. These cells mature in bone marrow in contrast to another class of immune cells that mature in the thymus.
ANSWER: B lymphocytes [or B cells; accept pro-B cells or pre-B cells; accept plasma cells]
[10m] One of these enzymes, first identified by Ogden Bruton, is defective in XLA. After cytokine receptors dimerize, the Janus type of these enzymes transphosphorylates each other at a certain amino acid residue.
ANSWER: tyrosine kinases [or TKs; accept Bruton’s tyrosine kinases or BTKs; accept Janus tyrosine kinases; accept receptor tyrosine kinases or RTKs; accept non-receptor tyrosine kinases or NRTKs; prompt on kinases; prompt on JAKs or JAK-STAT signaling]
[10h] During negative selection, self-reactive B cells can enter this state of unresponsiveness to any stimulatory signal. In the absence of co-stimulatory CD28, T cells enter this state via a calcium-dependent NFAT pathway.
ANSWER: anergy [accept clonal anergy; accept anergic state; reject “dormancy”]
<Michigan B, Biology> | Packet I - McGill B, UCLA A, Michigan B, Georgia Tech C, Southampton B
| Heard | PPB | E % | M % | H % |
|---|---|---|---|---|
| 63 | 10.48 | 68% | 27% | 10% |
Conversion
| Team | Opponent | Part 1 | Part 2 | Part 3 | Total | Parts |
|---|---|---|---|---|---|---|
| Carleton College | Washington B | 0 | 0 | 0 | 0 | |
| Claremont | Iowa State | 10 | 0 | 0 | 10 | E |
| Georgia Tech A | Minnesota A | 10 | 10 | 0 | 20 | EM |
| Missouri A | Washington A | 10 | 10 | 0 | 20 | EM |
Summary
| Tournament | Edition | Match | Heard | PPB | E % | M % | H % |
|---|---|---|---|---|---|---|---|
| California (North) | Main Site | ✓ | 3 | 16.67 | 100% | 67% | 0% |
| Canada | Main Site | ✓ | 1 | 10.00 | 100% | 0% | 0% |
| Florida | Main Site | ✓ | 3 | 6.67 | 33% | 0% | 33% |
| Lower Mid-Atlantic | Main Site | ✓ | 9 | 5.56 | 44% | 11% | 0% |
| Midwest | Main Site | ✓ | 9 | 11.11 | 56% | 33% | 22% |
| Northeast | Main Site | ✓ | 6 | 16.67 | 83% | 50% | 33% |
| Overflow | Main Site | ✓ | 4 | 12.50 | 75% | 50% | 0% |
| South Central | Main Site | ✓ | 2 | 10.00 | 100% | 0% | 0% |
| Southeast | Main Site | ✓ | 7 | 11.43 | 71% | 43% | 0% |
| UK | Main Site | ✓ | 6 | 8.33 | 50% | 17% | 17% |
| Upper Mid-Atlantic | Main Site | ✓ | 9 | 11.11 | 89% | 22% | 0% |
| Upstate NY | Main Site | ✓ | 4 | 7.50 | 75% | 0% | 0% |