Packet E: Bonus 7
Listeria monocytogenes derived ActA (“act-A”) induces the assembly of Arp2/3 (“arp-2-3”) complexes that promote polymerization of this protein in “comet tails.” For 10 points each:
[10e] Name this protein that forms microspikes at the lamellipodia edges of migrating cells. MreB (“M-R-E-B”) is the prokaryotic analog of this protein, whose microfilament structures bind to myosin heads during muscle contraction.
ANSWER: actin [accept F-actin or G-actin]
[10h] ActA acts as a mimic for an actin nucleation promoting factor mutated in this syndrome. This X-linked doubly eponymous syndrome is alternatively named after a triad of eczema, thrombocytopenia, and immunodeficiency.
ANSWER: Wiskott–Aldrich syndrome [or WAS; accept Wiskott–Aldrich syndrome protein or WASp; prompt on X-linked thrombocytopenia or XLT; prompt on X-linked congenital neutropenia or XLN]
[10m] In the “zipper” mechanism, Listeria invades host cells by binding surface internalins, which in turn interact with the epithelial form of this protein. Defects in these calcium-dependent cell adhesion proteins can trigger cancer cell metastasis.
ANSWER: cadherins [accept cadherin-1; accept E-cadherins or T-cadherins or P-cadherins; prompt on cads or E-cads or T-cads or P-cads]
<Johns Hopkins A, Biology> | Packet E - Chicago A, Toronto B, Brandeis B, JHU A
| Heard | PPB | E % | M % | H % |
|---|---|---|---|---|
| 75 | 10.53 | 79% | 23% | 4% |
Conversion
| Team | Opponent | Part 1 | Part 2 | Part 3 | Total | Parts |
|---|---|---|---|---|---|---|
| Catholic | Johns Hopkins B | 0 | 0 | 0 | 0 | |
| Columbia A | Maryland C | 10 | 10 | 10 | 30 | EHM |
| Columbia B | Maryland B | 10 | 0 | 10 | 20 | EM |
| Columbia C | Swarthmore | 10 | 0 | 0 | 10 | E |
| Georgetown | Rutgers B | 0 | 0 | 0 | 0 | |
| John Jay | NYU C | 10 | 0 | 10 | 20 | EM |
| NYU B | Vassar | 10 | 0 | 10 | 20 | EM |
| Rutgers A | Maryland A | 10 | 0 | 10 | 20 | EM |
Summary
| Tournament | Edition | Match | Heard | PPB | E % | M % | H % |
|---|---|---|---|---|---|---|---|
| California (North) | Main Site | ✓ | 3 | 16.67 | 100% | 67% | 0% |
| California (South) | Main Site | ✓ | 4 | 15.00 | 100% | 25% | 25% |
| Canada | Main Site | ✓ | 1 | 0.00 | 0% | 0% | 0% |
| Florida | Main Site | ✓ | 3 | 10.00 | 67% | 33% | 0% |
| Great Lakes | Main Site | ✓ | 5 | 10.00 | 100% | 0% | 0% |
| Lower Mid-Atlantic | Main Site | ✓ | 9 | 6.67 | 67% | 0% | 0% |
| Midwest | Main Site | ✓ | 8 | 17.50 | 100% | 63% | 13% |
| Northeast | Main Site | ✓ | 5 | 10.00 | 80% | 20% | 0% |
| Overflow | Main Site | ✓ | 4 | 5.00 | 50% | 0% | 0% |
| South Central | Main Site | ✓ | 2 | 5.00 | 50% | 0% | 0% |
| Southeast | Main Site | ✓ | 7 | 10.00 | 100% | 0% | 0% |
| UK | Main Site | ✓ | 12 | 7.50 | 58% | 17% | 0% |
| Upper Mid-Atlantic | Main Site | ✓ | 8 | 15.00 | 75% | 63% | 13% |
| Upstate NY | Main Site | ✓ | 4 | 10.00 | 100% | 0% | 0% |