Packet K: Tossup 1

One of these proteins has an unusual N-terminal ADP/ATP binding pocket that is targeted by geldanamycin. Another class of these proteins binds RpL23, contains a PPIase (“P-P-I-ace”) “head” domain, and are called trigger factors. GrpE (“grip-E”) and J-domain proteins augment the ATPase activity of some of these proteins. One of these proteins dissociates from ATF6, PERK, and IRE1 in a response pathway that (-5[1])usually triggers ERAD (“E-rad”). That one (-5[1])of these proteins is BiP. (10[1])The eukaryotic (10[1])TRiC and the prokaryotic (10[2])GroEL-GroES (10[7]-5[1])(“grow-E-L-grow-E-S”) complexes (10[2]-5[1])comprise the HSP60 (10[2])family (10[1])of these proteins, (10[1])which are upregulated (10[2])in response (-5[1])to heat shock. (10[2]-5[1])These proteins facilitate (10[1])hydrophobic (10[1])collapse, which allows (10[2])their (-5[1])“clients” to achieve proper tertiary structures. (10[1])For 10 points, (10[1])name these proteins that mediate (10[1])folding of (10[1])peptides. (10[2])■END■ (10[13]0[25])

Back to tossups

Buzzes

Summary