Round 12: Tossup 1

One of these proteins has an unusual N-terminal ADP/ATP binding pocket that is targeted by geldanamycin. Another class of these proteins binds RpL23, contains a PPIase (“P-P-I-ace”) “head” domain, and are called trigger factors. GrpE (“grip-E”) and J-domain proteins augment the ATPase activity of some of these proteins. One of these proteins dissociates from ATF6, PERK, and IRE1 in a response pathway that usually triggers ERAD (“E-rad”). That one of these proteins is BiP. The eukaryotic TRiC and the prokaryotic GroEL-GroES (10[1])(“grow-E-L-grow-E-S”) complexes (10[1])comprise the HSP60 family of these proteins, which are upregulated (10[2])in response to heat shock. These proteins facilitate hydrophobic (10[1])collapse, which allows their “clients” to achieve proper tertiary structures. For 10 points, name these proteins that mediate folding of peptides. ■END■ (10[3]0[6])

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