steroids - 2026 ACF Regionals

Packet K: Tossup 16

A derivative of one of these compounds contains additional dimethyl amino and acetate groups and is sold as ellaOne. Russell E. Marker synthesized one of these compounds by degrading diosgenin. The “suppression” of one of these compounds is measured in a test in which patients ingest a pill containing dexamethasone (10[2]-5[1])the night before. A natural precursor to one of these compounds (10[1])is formed by four concerted (10[1])cationic cyclization reactions from squalene (10[1])epoxide. (10[3])Premarin (10[2])is a conjugated equine (10[1]-5[1])type (10[1])of these compounds (10[1])that is sulfated (10[3])on the A ring of (10[1])their ABCD classification system. (10[2]-5[1])The adrenal cortex produces a class (10[2])of these compounds (10[2])prefixed by “mineral” (10[1])and “gluco.” (10[2]-5[2])For 10 points, name these lipids (10[1])with four (10[2])fused rings, (10[9])the (10[1])skeleton (10[2]-5[1])of most sex hormones. (10[1])■END■ (10[9]0[11])

ANSWER: steroids [accept steroid hormones; accept sterols or cholesterol or lanosterol or 24-dehydrocholesterol; accept sex hormones until read; accept progesterone or estrogen or estradiol; accept Premarin until read; accept conjugated estrogens or CEs or conjugated equine estrogens or CEEs; accept cortisol or corticoids or mineralocorticoids or glucocorticoids or corticosteroids; accept dexamethasone until read; prompt on hormones; prompt on lipids or fats; prompt on terpenes or terpenoids or isoprenoids; prompt on combined oral contraceptives or emergency contraception or birth control pills by asking “what class of compounds are active?”; reject “phospholipids”] (The first sentence refers to ulipristal acetate.)

<Durham A, Chemistry> | Packet K - UCF A, Notre Dame B, Durham A, Michigan State A, Swarthmore A, Cambridge B

= Average correct buzzpoint

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Buzzes

Player	Team	Opponent	Buzzpoint	Value
Caleb Ott	Waterloo A	McMaster A	49	10
Nathan Easow	Manchester	Southampton B	49	-5
Zachary Joseph	Columbia B	Columbia C	49	10
Moses Kitakule	Columbia A	Rutgers B	60	10
Matthew Forster	Dartmouth A	Yale	65	10
Yashwanth Bajji	Michigan A	Michigan B	70	10
Rohan Ganeshan	Harvard A	Brandeis A	71	10
Oscar Despard	Cambridge A	Imperial B	71	10
Sinecio Morales	Johns Hopkins A	Maryland A	71	10
Ethan Ririe	UCSD C	UC Santa Barbara	72	10
Mason Yu	Brown	Brandeis B	72	10
Eva Mandelbaum	Guelph	McGill A	76	10
Russell Nip	UBC A	Toronto B	76	-5
Pace Klein	CWRU A	Ohio State B	77	10
Rayhana Amjad	Edinburgh A	Warwick A	80	10
Karthik Jayaram	UCLA A	UCSD A	83	10
Jonathan Huang	MIT	Bowdoin B	83	10
Charles Hang	WashU A	Georgia Tech B	83	10
Ilyas Choukri	Virginia Tech A	VCU	88	10
Tiffany Zhou	Ohio State A	Pittsburgh	92	10
Foster Hughes	Minnesota A	Missouri A	92	10
Vikshar Athreya	Rutgers A	John Jay	92	-5
Emily Kadolph	Virginia Tech B	North Carolina B	98	10
Harri Slaughter	Cardiff	Oxford C	98	10
Alden Thompson	Carleton University	Waterloo B	101	10
Michael Wu	Southampton A	Birmingham	101	10
Monish Jampala	Georgia Tech D	Georgia Tech C	104	10
Brendan Bridle	Queen's	Ottawa	106	10
Connor Ronan	South Carolina B	William and Mary	106	-5
Nathan Woolery	Louisville B	Bruin	106	-5
Snehan Saroch	Louisville A	Sewanee	106	10
Nihal Jacob	Kentucky	Mississipi State	112	10
Max Polsky	Western B	Toronto D	114	10
Samanyu Dixit	North Carolina C	North Carolina A	114	10
March Delfin	UCSD B	UCLA B	116	10
Kevin Ye	Simon Fraser	McGill B	116	10
Yoyo Liu	UBC B	Toronto E	116	10
Jacob Goodson	Ohio State C	CWRU B	116	10
Jesse Mindel	NC State A	James Madison B	116	10
Caleb Slusher	South Carolina A	James Madison A	116	10
Elokkin Pate-Geames	Tennessee B	Alabama B	116	10
Katie Farthing	Vanderbilt B	WashU B	116	10
Xavier Bornhorst	Maryland B	NYU C	116	10
Athan Juritsch	Toronto G	Toronto C	117	10
Parker McCoig	Tennessee A	Alabama A	118	10
Danny Fisher	Warwick B	Montpellier	118	-5
Ryan Rosenberg	NYU A	Catholic	118	10
Roselyn Daffin	Southampton B	Manchester	122	10
Ruby Xia	Arizona State	UC Irvine	123	10
Raymond Chen	Toronto B	UBC A	123	10
Cameron Liu	Toronto F	Toronto Metropolitan	123	10
Owen Banks	Duke	Liberty B	123	0
Abby Keith	Liberty B	Duke	123	0
Nathan Redford	Liberty A	Wake Forest	123	0
Deeba Lealaz	Virginia	Liberty C	123	10
Samuel Li	William and Mary	South Carolina B	123	0
Neiman Mocombe	Bowdoin A	Dartmouth B	123	0
Christopher Bradley	Southern Connecticut State	Harvard B	123	0
Max Neal	Harvard B	Southern Connecticut State	123	10
Drew Wetterlind	Iowa State	Missouri B	123	0
Safiya Hasan	Missouri B	Iowa State	123	0
George Matsumura	Washington A	Washington B	123	10
Jack Lewis	Bruin	Louisville B	123	10
Krishna Girish	Montpellier	Warwick B	123	10
Jerry Vinokurov	John Jay	Rutgers A	123	0
Asher Lyons	Maryland C	Johns Hopkins B	123	0
Jarman Taylor	Johns Hopkins B	Maryland C	123	0
Kelvin Ni	NYU B	Georgetown	123	10

Summary

Tournament	Edition	Match	Heard	Conv. %	Neg %	Avg. Buzz
California (South)	Main Site	✓	4	100%	0%	98.50
Canada	Main Site	✓	12	83%	8%	104.10
Great Lakes	Main Site	✓	4	100%	0%	88.75
Lower Mid-Atlantic	Main Site	✓	9	67%	11%	109.17
Northeast	Main Site	✓	6	83%	0%	82.80
Overflow	Main Site	✓	3	67%	0%	107.50
Southeast	Main Site	✓	8	100%	13%	109.75
UK	Main Site	✓	6	100%	33%	99.17
Upper Mid-Atlantic	Main Site	✓	8	75%	13%	89.50