steroids - Upper Mid-Atlantic

Round 4: Tossup 16

A derivative of one of these compounds contains additional dimethyl amino and acetate groups and is sold as ellaOne. Russell E. Marker synthesized one of these compounds by degrading diosgenin. The “suppression” of one of these compounds is measured in a test in which patients ingest a pill containing dexamethasone (10[1])the night before. A natural precursor to one of these compounds (10[1])is formed by four concerted cationic cyclization reactions from squalene epoxide. (10[1])Premarin is a conjugated equine type of these compounds that is sulfated on the A ring of their ABCD classification system. (-5[1])The adrenal cortex produces a class of these compounds prefixed by “mineral” and “gluco.” For 10 points, name these lipids with four fused rings, (10[1])the skeleton (10[1])of most sex hormones. ■END■ (10[1]0[3])

ANSWER: steroids [accept steroid hormones; accept sterols or cholesterol or lanosterol or 24-dehydrocholesterol; accept sex hormones until read; accept progesterone or estrogen or estradiol; accept Premarin until read; accept conjugated estrogens or CEs or conjugated equine estrogens or CEEs; accept cortisol or corticoids or mineralocorticoids or glucocorticoids or corticosteroids; accept dexamethasone until read; prompt on hormones; prompt on lipids or fats; prompt on terpenes or terpenoids or isoprenoids; prompt on combined oral contraceptives or emergency contraception or birth control pills by asking “what class of compounds are active?”; reject “phospholipids”] (The first sentence refers to ulipristal acetate.)

<Durham A, Chemistry> | Packet K - UCF A, Notre Dame B, Durham A, Michigan State A, Swarthmore A, Cambridge B

= Average correct buzzpoint

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Buzzes

Player	Team	Opponent	Buzzpoint	Value
Zachary Joseph	Columbia B	Columbia C	49	10
Moses Kitakule	Columbia A	Rutgers B	60	10
Sinecio Morales	Johns Hopkins A	Maryland A	71	10
Vikshar Athreya	Rutgers A	John Jay	92	-5
Xavier Bornhorst	Maryland B	NYU C	116	10
Ryan Rosenberg	NYU A	Catholic	118	10
Jerry Vinokurov	John Jay	Rutgers A	123	0
Asher Lyons	Maryland C	Johns Hopkins B	123	0
Jarman Taylor	Johns Hopkins B	Maryland C	123	0
Kelvin Ni	NYU B	Georgetown	123	10

Summary

Tournament	Edition	Match	Heard	Conv. %	Neg %	Avg. Buzz
California (South)	Main Site	✓	4	100%	0%	98.50
Canada	Main Site	✓	12	83%	8%	104.10
Great Lakes	Main Site	✓	4	100%	0%	88.75
Lower Mid-Atlantic	Main Site	✓	9	67%	11%	109.17
Northeast	Main Site	✓	6	83%	0%	82.80
Overflow	Main Site	✓	3	67%	0%	107.50
Southeast	Main Site	✓	8	100%	13%	109.75
UK	Main Site	✓	6	100%	33%	99.17
Upper Mid-Atlantic	Main Site	✓	8	75%	13%	89.50