vesicles - 2026 ACF Regionals

Packet H: Tossup 10

Electroformation is used to generate the “giant unilamellar” type of these structures. (10[3])These structures can be assembled using a protein that has “helix-break-helix” motifs and is called caveolin-1. A protein (10[1])involved in assembling another type of (10[1])these structures contains PIP2 (“pip-two”)-binding ANTH (10[1])domains and links AP2 adaptor complexes (10[2])with a triskelion-shaped protein (10[1]-5[1])that coats (10[2])these structures. (10[5]-5[1])Rab GTPases (10[1])(“G-T-P-aces”) help tether these structures prior to SNARE (10[1])(“snair”)-mediated fusion. (10[7]-5[2])Sec13/31 (10[4]-5[1])(“seck-13-31”) is recruited to assemble COPII (10[1])(“cop-two”) complexes (10[2])around these structures, (10[1])which (-5[1])are analogous (10[1])to their clathrin-coated types. (10[2])Receptor-mediated (-5[1])endocytosis (-5[1])forms these structures, (-5[1])which also (10[2])compartmentalize (10[1])cargo (10[2])by the trans-Golgi (10[3])network. (10[4])For 10 points, (10[2])name these membrane-bound (10[1]-5[1])structures (10[1])used for (10[1]-5[1])trafficking. (10[1]-5[1])■END■ (10[11]0[8])

ANSWER: vesicles [accept transport or secretory or intracellular vesicles; accept extracellular vesicles or EVs or exosomes; accept giant unilamellar vesicles or GUVs until read; accept COPI-, COPII-, or clathrin-coated vesicles; accept multivesicular bodies or MBVs; accept late or early endosomes; accept liposomes; prompt on lipid membranes (until read) or lipid bilayers or phospholipids or lipids; reject “micelles”; reject “organelles” or “lysosomes” or “peroxisomes”] (The third sentence refers to AP180 or CALM or clathrin-assembly lymphoid myeloid leukemia protein.)

<Ohio State C, Biology> | Packet H - Yale A, Ohio State C, Illinois C, Virginia Tech B, MIT A

= Average correct buzzpoint

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Buzzes

Player	Team	Opponent	Buzzpoint	Value
Vinu Harihar	Berkeley B	Berkeley C	11	10
Tiffany Zhou	Ohio State A	Michigan A	11	10
Oscar Despard	Cambridge A	Bristol	11	10
Andrew Wang	Illinois A	Northwestern D	29	10
Shiva Tegulla	Central Florida A	Central Florida B	35	10
Jason Zhang	Toronto B	Waterloo A	40	10
Karthik Jayaram	UCLA A	UCLA B	46	10
Patrick Boyle	Notre Dame A	Chicago C	46	10
Ben Hellman	Swarthmore	Maryland A	50	10
Kelvin Ni	NYU B	Columbia A	50	-5
Alex Akridge	Indiana A	Indiana B	52	10
David Bass	Johns Hopkins A	NYU C	52	10
Fish Tsai	UCSD A	Arizona State	54	10
Rachel Fanous	Michigan B	Pittsburgh	54	10
Samarth Ram	Chicago B	Indiana C	54	10
Matthew He	Texas A	Texas B	54	10
Roselyn Daffin	Southampton B	Cambridge C	54	10
Arvin Boraghi	Cambridge B	Warwick A	54	-5
Xavier Bornhorst	Maryland B	Columbia C	56	10
Ryan Rosenberg	NYU A	Vassar	63	10
Swapnil Garg	Berkeley A	Stanford B	64	10
Pace Klein	CWRU A	Michigan C	64	10
Tianyu Xu	Georgia Tech B	Tennessee A	64	10
Jack Lewis	Bruin	Georgia Tech C	64	10
Monish Jampala	Georgia Tech D	Louisville B	64	10
Ali Hamzeh	Edinburgh A	Imperial A	64	10
Ted Harrison	Edinburgh B	Montpellier	64	10
Vikshar Athreya	Rutgers A	Columbia B	64	-5
Alec Riso	Cornell A	RIT	64	-5
Yoyo Liu	UBC B	Guelph	65	10
Christian Humeniuk	McMaster A	Ottawa	65	10
Russell Nip	UBC A	Queen's	65	10
Yash Tiwari	Minnesota A	Iowa State	65	10
Rohan Dalal	Georgia Tech A	Missouri B	65	-5
Virginia Stewart	Alabama B	WashU B	70	10
Victor Xu	Toronto G	McGill B	71	10
Jason Thieu	Michigan State	CWRU B	71	10
Eric Yang	Purdue A	Chicago D	74	10
Logan Mathis	WashU A	Alabama A	75	-5
Camrun Scott	Murray State A	Texas A&M A	77	10
Rishabh Dave	Berkeley D	Stanford A	81	10
Azura Gollamudi	Northwestern B	Chicago A	81	10
March Delfin	UCSD B	UC Santa Barbara	82	-5
Charlotte Wilcox	Western C	Toronto C	83	-5
Eveline Ong	Oxford A	Manchester	86	-5
Jiping Fang	Illinois B	Notre Dame B	88	10
Akshay Seetharam	Claremont	Washington B	88	10
Pranaav Senthilkumar	Cornell B	Penn State	89	10
Dawson Teu	Waterloo B	Toronto E	90	10
Katie Farthing	Vanderbilt B	Tennessee B	90	10
Ethan Ririe	UCSD C	UC Irvine	93	10
Mariella Michael	Oxford C	Oxford B	93	10
Alan Li	Cornell C	Binghamton B	93	10
Kevin Ye	Simon Fraser	Brock	94	10
Ethen Sun	Toronto D	Western A	94	10
Bonham Buchannon	Louisville A	Kentucky	94	10
Harri Slaughter	Cardiff	City St. George's	94	10
Alden Thompson	Carleton University	McGill A	97	10
Isabel Dent	Sewanee	Mississipi State	97	10
Max Polsky	Western B	Toronto F	100	-5
Samuel Lipsutz	Chicago E	Purdue B	100	10
Harris Beckner	Alabama A	WashU A	101	10
Michael Wu	Southampton A	UCL	103	10
Peter Smith	Binghamton A	Rochester	103	-5
George Matsumura	Washington A	Carleton College	104	-5
Nathan Easow	Manchester	Oxford A	104	10
Winston Zuo	UC Santa Barbara	UCSD B	105	0
Saju Ramraj	Toronto F	Western B	105	0
Ishan Joshi	Toronto Metropolitan	McMaster B	105	0
Yusuf Baig	McMaster B	Toronto Metropolitan	105	0
Deepanshi Matai	Toronto C	Western C	105	0
Thomas Tibbetts	Central Florida C	Florida A	105	10
Khanh Nguyen	Florida C	Florida B	105	10
Dominik Polley	Carleton College	Washington A	105	10
Jack Funke	Missouri B	Georgia Tech A	105	0
Aisling Skeet	Durham	Birmingham	105	10
Gus Redding	Imperial B	LSE	105	10
Danny Fisher	Warwick B	Imperial C	105	10
Chris Levesley	Warwick A	Cambridge B	105	10
Cole Hartung	Georgetown	Johns Hopkins B	105	0
Aiden Bang	Johns Hopkins B	Georgetown	105	10
Moses Kitakule	Columbia A	NYU B	105	10
Zachary Joseph	Columbia B	Rutgers A	105	10
Killian Simonson	Rochester	Binghamton A	105	0
Cade Reinberger	RIT	Cornell A	105	10

Summary

Tournament	Edition	Match	Heard	Conv. %	Neg %	Avg. Buzz
California (North)	Main Site	✓	3	100%	0%	52.00
California (South)	Main Site	✓	4	75%	25%	64.33
Canada	Main Site	✓	12	75%	17%	75.67
Florida	Main Site	✓	3	100%	0%	81.67
Great Lakes	Main Site	✓	4	100%	0%	50.00
Midwest	Main Site	✓	8	100%	0%	65.50
Overflow	Main Site	✓	4	75%	50%	86.00
South Central	Main Site	✓	2	100%	0%	65.50
Southeast	Main Site	✓	8	100%	13%	80.50
UK	Main Site	✓	12	100%	17%	83.92
Upper Mid-Atlantic	Main Site	✓	8	88%	25%	76.57
Upstate NY	Main Site	✓	4	75%	50%	95.67