Packet D: Bonus 6
A 2015 study by Singh et al. found that HIV-1 prefers integration into genes where transcription and this other downstream process are both highly active. For 10 points each:
[10m] Name this process that involves the assembly of U1 to U6 snRNPs (“snurps”) into its namesake complex. HIV-1 hijacks host machinery to perform this process using four donor and seven acceptor sites.
ANSWER: RNA splicing [or word forms; accept alternative splicing; accept minor or major spliceosome assembly]
[10e] Early, unspliced HIV-1 transcripts are transported out of this organelle after Rev proteins bind exportin and Ran-GTP. Splicing factors are concentrated in Cajal bodies found in this organelle, which stores genomic DNA.
ANSWER: cellular nucleus [or cellular nuclei]
[10h] HIV-1 also evades this pathway by sequestering UPF1, a core component of its SURF complex. mRNA splicing errors are corrected by this pathway, which is triggered by the retention of exon-exon junction complexes.
ANSWER: nonsense-mediated decay [or NMD; prompt on mRNA decay; prompt on mRNA surveillance; reject “non-stop decay”]
<Oxford A, Biology> | Packet D - UBC B, Oxford A, Waterloo B, CWRU A
| Heard | PPB | E % | M % | H % |
|---|---|---|---|---|
| 69 | 12.61 | 96% | 26% | 4% |
Conversion
| Team | Opponent | Part 1 | Part 2 | Part 3 | Total | Parts |
|---|---|---|---|---|---|---|
| Catholic | Columbia A | 0 | 10 | 0 | 10 | E |
| Columbia B | John Jay | 10 | 10 | 0 | 20 | ME |
| Georgetown | Vassar | 0 | 10 | 0 | 10 | E |
| Johns Hopkins A | Rutgers A | 10 | 10 | 10 | 30 | MEH |
| Maryland A | NYU C | 0 | 10 | 0 | 10 | E |
| Maryland C | Rutgers B | 0 | 10 | 0 | 10 | E |
| NYU A | NYU B | 0 | 10 | 0 | 10 | E |
| Swarthmore | Maryland B | 10 | 10 | 0 | 20 | ME |
Summary
| Tournament | Edition | Match | Heard | PPB | E % | M % | H % |
|---|---|---|---|---|---|---|---|
| California (North) | Main Site | ✓ | 3 | 10.00 | 100% | 0% | 0% |
| California (South) | Main Site | ✓ | 4 | 15.00 | 100% | 50% | 0% |
| Florida | Main Site | ✓ | 3 | 10.00 | 100% | 0% | 0% |
| Great Lakes | Main Site | ✓ | 4 | 10.00 | 75% | 25% | 0% |
| Lower Mid-Atlantic | Main Site | ✓ | 9 | 12.22 | 89% | 33% | 0% |
| Midwest | Main Site | ✓ | 9 | 12.22 | 100% | 11% | 11% |
| Northeast | Main Site | ✓ | 6 | 16.67 | 100% | 67% | 0% |
| Overflow | Main Site | ✓ | 4 | 10.00 | 100% | 0% | 0% |
| South Central | Main Site | ✓ | 2 | 10.00 | 50% | 50% | 0% |
| Southeast | Main Site | ✓ | 7 | 11.43 | 100% | 14% | 0% |
| UK | Main Site | ✓ | 6 | 15.00 | 100% | 33% | 17% |
| Upper Mid-Atlantic | Main Site | ✓ | 8 | 15.00 | 100% | 38% | 13% |
| Upstate NY | Main Site | ✓ | 4 | 10.00 | 100% | 0% | 0% |